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The role of a System Owner in information security is primarily focused on ensuring that the system operates effectively and securely within the defined organizational policies and procedures. The System Owner is accountable for the overall management and administration of a particular information system, which includes its hardware and software configuration. This involves defining configuration management processes that help maintain the integrity and security of the system throughout its lifecycle.

The responsibilities of a System Owner also extend to ensuring that the system meets security requirements, aligning with organizational security standards, and addressing any identified vulnerabilities or security concerns. They play a critical role in the execution of security policies by configuring the system in a way that minimizes risks and protects sensitive data.

While compliance audits, physical security measures, and vulnerability assessments are vital components of an organization's information security program, they typically fall under the purview of other roles or functions such as compliance officers, physical security teams, and security analysts, respectively. Their practitioners may work closely with the System Owner to ensure the system adheres to established guidelines and best practices, but the System Owner’s primary focus is on hardware and software configuration management.